MRPL23 (NM_021134) Human Recombinant Protein

• Background:

  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]

• Synonyms:

  L23MRP; RPL23; RPL23L

• Gene ID:

  6150

• UniProt:

  Q16540, A0A024RCB2

• Accession Number mRNA:

  NM_021134

• Chromosomal Location:

  11p15.5

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Function:

  Druggable Genome

• Molecular Weight:

  17.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MRPL23

• Species:

  Human

• Protein ID:

  NP_066957

• Overview:

  Recombinant protein of human mitochondrial ribosomal protein L23 (MRPL23), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6150

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16540

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021134

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_066957