CNOT2 (NM_014515) Human Recombinant Protein

• Background:

  This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

• Synonyms:

  CDC36; HSPC131; IDNADFS; NOT2; NOT2H

• Gene ID:

  4848

• UniProt:

  Q9NZN8, A0A024RBD8

• Accession Number mRNA:

  NM_014515

• Chromosomal Location:

  12q15

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  RNA degradation

• Field of Research:

  RNA degradation

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Function:

  Transcription Factors

• Molecular Weight:

  59.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CNOT2

• Species:

  Human

• Protein ID:

  NP_055330

• Overview:

  Recombinant protein of human CCR4-NOT transcription complex, subunit 2 (CNOT2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4848

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NZN8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014515

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055330