RUNX2 (NM_004348) Human Recombinant Protein

• Background:

  This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

• Synonyms:

  AML3; CBFA1; CCD; CCD1; OSF-2; OSF2; PEA2aA; PEBP2A1; PEBP2A2; PEBP2aA; PEBP2aA1

• Gene ID:

  860

• UniProt:

  Q13950

• Accession Number mRNA:

  NM_004348

• Chromosomal Location:

  6p21.1

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  54.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RUNX2

• Species:

  Human

• Protein ID:

  NP_004339

• Overview:

  Recombinant protein of human runt-related transcription factor 2 (RUNX2), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/860

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13950

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004348

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004339