LYK5 (STRADA) (NM_153335) Human Recombinant Protein

• Background:

  The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25) . The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

• Synonyms:

  LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRAD alpha

• Gene ID:

  92335

• UniProt:

  Q7RTN6

• Accession Number mRNA:

  NM_153335

• Chromosomal Location:

  17q23.3

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  MTOR signaling pathway

• Field of Research:

  MTOR signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  38.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  STRADA

• Species:

  Human

• Protein ID:

  NP_699166

• Overview:

  Purified recombinant protein of Homo sapiens STE20-related kinase adaptor alpha (STRADA), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/92335

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q7RTN6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_153335

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_699166