Dectin 1 (CLEC7A) (NM_197950) Human Recombinant Protein

• Background:

  This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

• Synonyms:

  BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2

• Gene ID:

  64581

• UniProt:

  Q9BXN2, Q68D78

• Accession Number mRNA:

  NM_197950

• Chromosomal Location:

  12p13.2

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  19 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CLEC7A

• Species:

  Human

• Protein ID:

  NP_922941

• Overview:

  Purified recombinant protein of Human C-type lectin domain family 7, member A (CLEC7A), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/64581

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BXN2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_197950

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_922941