AP2 beta (TFAP2B) (NM_003221) Human Recombinant Protein

• Background:

  This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

• Synonyms:

  AP-2B; AP-2beta; AP2-B; PDA2

• Gene ID:

  7021

• UniProt:

  Q92481

• Accession Number mRNA:

  NM_003221

• Chromosomal Location:

  6p12.3

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  50.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TFAP2B

• Species:

  Human

• Protein ID:

  NP_003212

• Overview:

  Purified recombinant protein of Human transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (TFAP2B), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7021

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92481

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003221

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003212