Interferon gamma (IFNG) (NM_000619) Human Recombinant Protein

• Background:

  This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

• Synonyms:

  IFG; IFI; IMD69

• Gene ID:

  3458

• UniProt:

  P01579

• Accession Number mRNA:

  NM_000619

• Chromosomal Location:

  12q15

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Allograft rejection, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Proteasome, Regulation of autophagy, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Type I diabetes mellitus

• Field of Research:

  Allograft rejection, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Proteasome, Regulation of autophagy, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Type I diabetes mellitus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  16.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  IFNG

• Species:

  Human

• Protein ID:

  NP_000610

• Overview:

  Purified recombinant protein of Human interferon, gamma (IFNG), with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3458

• Uniprot URL:

  https://www.uniprot.org/uniprot/P01579

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000619

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000610