PDE1C (NM_005020) Human Recombinant Protein

• Background:

  This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

• Synonyms:

  Cam-PDE 1C; DFNA74; hCam-3; Hcam3

• Gene ID:

  5137

• UniProt:

  Q14123

• Accession Number mRNA:

  NM_005020

• Chromosomal Location:

  7p14.3

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  29860631

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome

• Molecular Weight:

  72 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE1C

• Species:

  Human

• Protein ID:

  NP_005011

• Overview:

  Purified recombinant protein of Human phosphodiesterase 1C, calmodulin-dependent 70kDa (PDE1C), transcript variant 4, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5137

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q14123

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005020

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005011