Caspase 2 (CASP2) (NM_032982) Human Recombinant Protein

• Background:

  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

• Synonyms:

  CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57

• Gene ID:

  835

• UniProt:

  P42575, A0A0S2Z3H1

• Accession Number mRNA:

  NM_032982

• Chromosomal Location:

  7q34

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome, Protease

• Molecular Weight:

  50.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CASP2

• Species:

  Human

• Protein ID:

  NP_116764

• Overview:

  Purified recombinant protein of Human caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/835

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42575

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_032982

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_116764