TCF4 (NM_003199) Human Recombinant Protein

• Background:

  This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

• Synonyms:

  BHLHb19; CDG2T; E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4

• Gene ID:

  6925

• UniProt:

  P15884, B3KVA4, A0A024R2C0

• Accession Number mRNA:

  NM_003199

• Chromosomal Location:

  18q21.2

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

• Molecular Weight:

  71.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TCF4

• Species:

  Human

• Protein ID:

  NP_003190

• Overview:

  Purified recombinant protein of Human transcription factor 4 (TCF4), transcript variant 2, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6925

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15884

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003199

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003190