Calcipressin 1 (RCAN1) (NM_203417) Human Recombinant Protein

• Background:

  The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

• Synonyms:

  ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1

• Gene ID:

  1827

• UniProt:

  P53805

• Accession Number mRNA:

  NM_203417

• Chromosomal Location:

  21q22.12

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Transcription Factors

• Molecular Weight:

  13.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RCAN1

• Species:

  Human

• Protein ID:

  NP_981962

• Overview:

  Purified recombinant protein of Human regulator of calcineurin 1 (RCAN1), transcript variant 2, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1827

• Uniprot URL:

  https://www.uniprot.org/uniprot/P53805

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_203417

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_981962