SMAD5 (NM_005903) Human Recombinant Protein

• Background:

  The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Synonyms:

  DWFC; JV5-1; MADH5

• Gene ID:

  4090

• UniProt:

  Q99717, Q68DB7

• Accession Number mRNA:

  NM_005903

• Chromosomal Location:

  5q31.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  TGF-beta signaling pathway

• Field of Research:

  TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors

• Molecular Weight:

  52.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SMAD5

• Species:

  Human

• Protein ID:

  NP_005894

• Overview:

  Purified recombinant protein of Human SMAD family member 5 (SMAD5), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4090

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99717

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005903

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005894