NSE2 (NSMCE2) (NM_173685) Human Recombinant Protein

• Background:

  This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]

• Synonyms:

  C8orf36; MMS21; NSE2; ZMIZ7

• Gene ID:

  286053

• UniProt:

  Q96MF7, A0A024R9J6

• Accession Number mRNA:

  NM_173685

• Chromosomal Location:

  8q24.13

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Molecular Weight:

  27.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NSMCE2

• Species:

  Human

• Protein ID:

  NP_775956

• Overview:

  Purified recombinant protein of Human non-SMC element 2, MMS21 homolog (S. cerevisiae) (NSMCE2), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/286053

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96MF7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_173685

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_775956