TBLR1 (TBL1XR1) (NM_024665) Human Recombinant Protein

• Background:

  This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta) -like 1X-linked (TBL1X) . The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

• Synonyms:

  C21; DC42; IRA1; MRD41; TBLR1

• Gene ID:

  79718

• UniProt:

  Q9BZK7

• Accession Number mRNA:

  NM_024665

• Chromosomal Location:

  3q26.32

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Wnt signaling pathway

• Field of Research:

  Wnt signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  55.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TBL1XR1

• Species:

  Human

• Protein ID:

  NP_078941

• Overview:

  Purified recombinant protein of Human transducin (beta) -like 1 X-linked receptor 1 (TBL1XR1), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/79718

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BZK7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_024665

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_078941