HIST1H2AK (HIST1H2AL) (NM_003511) Human Recombinant Protein

• Background:

  Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

• Synonyms:

  DJ193B12.9; H2A.i; H2A/i; H2AC11; H2AC13; H2AC15; H2AC17; H2AFI; HIST1H2AL

• Gene ID:

  8332

• UniProt:

  P0C0S8, A4FTV9

• Accession Number mRNA:

  NM_003511

• Chromosomal Location:

  6p22.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Systemic lupus erythematosus

• Field of Research:

  Systemic lupus erythematosus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0

• Molecular Weight:

  13.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HIST1H2AL

• Species:

  Human

• Protein ID:

  NP_003502

• Overview:

  Purified recombinant protein of human histone cluster 1, H2al (HIST1H2AL), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8332

• Uniprot URL:

  https://www.uniprot.org/uniprot/P0C0S8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003511

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003502