Ubiquitin (UBB) (NM_018955) Human Recombinant Protein

• Background:

  This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Synonyms:

  HEL-S-50

• Gene ID:

  7314

• UniProt:

  P0CG47, Q5U5U6

• Accession Number mRNA:

  NM_018955

• Chromosomal Location:

  17p11.2

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Parkinson's disease

• Field of Research:

  Parkinson's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

• Function:

  Druggable Genome

• Molecular Weight:

  25.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  UBB

• Species:

  Human

• Protein ID:

  NP_061828

• Overview:

  Purified recombinant protein of Human ubiquitin B (UBB), full length, with N-terminal HIS tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7314

• Uniprot URL:

  https://www.uniprot.org/uniprot/P0CG47

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018955

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_061828