AP4S1 (NM_007077) Human Recombinant Protein

• Background:

  This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]

• Synonyms:

  AP47B; CLA20; CLAPS4; CPSQ6; SPG52

• Gene ID:

  11154

• UniProt:

  Q9Y587

• Accession Number mRNA:

  NM_007077

• Chromosomal Location:

  14q12

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Lysosome

• Field of Research:

  Lysosome

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Molecular Weight:

  18.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  AP4S1

• Species:

  Human

• Protein ID:

  NP_009008

• Overview:

  Purified recombinant protein of Human adaptor-related protein complex 4, sigma 1 subunit (AP4S1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11154

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y587

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007077

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_009008