Caspase 1 (CASP1) (NM_033292) Human Recombinant Protein

• Background:

  This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

• Synonyms:

  ICE; IL1BC; P45

• Gene ID:

  834

• UniProt:

  P29466

• Accession Number mRNA:

  NM_033292

• Chromosomal Location:

  11q22.3

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Amyotrophic lateral sclerosis (ALS), Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

• Field of Research:

  Amyotrophic lateral sclerosis (ALS), Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome, Protease

• Molecular Weight:

  45 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CASP1

• Species:

  Human

• Protein ID:

  NP_150634

• Overview:

  Purified recombinant protein of -Human caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant alpha, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/834

• Uniprot URL:

  https://www.uniprot.org/uniprot/P29466

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_033292

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_150634