MACROH2A1 (NM_001040158) Human Recombinant Protein

• Background:

  Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

• Synonyms:

  H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1.1; macroH2A1.2; mH2A1

• Gene ID:

  9555

• UniProt:

  O75367

• Accession Number mRNA:

  NM_001040158

• Chromosomal Location:

  5q31.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Systemic lupus erythematosus

• Field of Research:

  Systemic lupus erythematosus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Molecular Weight:

  39.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MACROH2A1

• Species:

  Human

• Protein ID:

  NP_001035248

• Overview:

  Purified recombinant protein of Human H2A histone family, member Y (H2AFY), transcript variant 4, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9555

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75367

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001040158

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001035248