PITX2 (NM_000325) Human Recombinant Protein

• Background:

  This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

• Synonyms:

  ARP1; ASGD4; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PTX2; RGS; RIEG; RIEG1; RS

• Gene ID:

  5308

• UniProt:

  Q99697, Q99697-2

• Accession Number mRNA:

  NM_000325

• Chromosomal Location:

  4q25

• Expression System:

  E. coli

• Tag:

  N-GST and C-His

• Related Pathways:

  TGF-beta signaling pathway

• Field of Research:

  TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

• Function:

  Transcription Factors

• Molecular Weight:

  61.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PITX2

• Species:

  Human

• Protein ID:

  NP_000316

• Overview:

  Purified recombinant protein of Human paired-like homeodomain 2 (PITX2), transcript variant 3, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5308

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99697

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000325

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000316