Hepsin (HPN) (NM_002151) Human Recombinant Protein

• Background:

  This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

• Synonyms:

  TMPRSS1

• Gene ID:

  3249

• UniProt:

  P05981, A0A140VJK9

• Accession Number mRNA:

  NM_002151

• Chromosomal Location:

  19q13.11

• Expression System:

  E. coli

• Tag:

  N-GST and C-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea.

• Function:

  Druggable Genome, Protease, Transmembrane

• Molecular Weight:

  72.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HPN

• Species:

  Human

• Protein ID:

  NP_002142

• Overview:

  Purified recombinant protein of Human hepsin (HPN), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3249

• Uniprot URL:

  https://www.uniprot.org/uniprot/P05981

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002151

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002142