ITM2C (NM_001012516) Human Recombinant Protein

• Background:

  Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  BRI3; BRICD2C; E25; E25C; ITM3

• Gene ID:

  81618

• UniProt:

  Q9NQX7

• Accession Number mRNA:

  NM_001012516

• Chromosomal Location:

  2q37.1

• Expression System:

  E. coli

• Tag:

  N-GST and C-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea.

• Function:

  Transmembrane

• Molecular Weight:

  53.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ITM2C

• Species:

  Human

• Protein ID:

  NP_001012534

• Overview:

  Purified recombinant protein of Human integral membrane protein 2C (ITM2C), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/81618

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NQX7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001012516

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001012534