RNF183 (NM_145051) Human Recombinant Protein

• Background:

  Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230) . Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230) . May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  FLJ31197; MGC4734

• Gene ID:

  138065

• UniProt:

  Q96D59, A0A024R834

• Accession Number mRNA:

  NM_145051

• Chromosomal Location:

  9q32

• Expression System:

  E. coli

• Tag:

  N-GST and C-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea.

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  49.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RNF183

• Species:

  Human

• Protein ID:

  NP_659488

• Overview:

  Purified recombinant protein of Human ring finger protein 183 (RNF183), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/138065

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96D59

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_145051

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_659488