WNT6 (NM_006522) Human Recombinant Protein

• Background:

  The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]

• Gene ID:

  7475

• UniProt:

  Q9Y6F9, Q8N2E5

• Accession Number mRNA:

  NM_006522

• Chromosomal Location:

  2q35

• Expression System:

  E. coli

• Tag:

  N-His-ABP

• Related Pathways:

  Basal cell carcinoma, Hedgehog signaling pathway, Melanogenesis, Pathways in cancer, Wnt signaling pathway

• Field of Research:

  Basal cell carcinoma, Hedgehog signaling pathway, Melanogenesis, Pathways in cancer, Wnt signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol

• Function:

  Adult stem cells, Cancer stem cells, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway, Transmembrane

• Molecular Weight:

  20.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  WNT6

• Species:

  Human

• Protein ID:

  NP_006513

• Overview:

  Purified recombinant protein of Human wingless-type MMTV integration site family, member 6 (WNT6), Pro32-Phe82, with N-terminal His-ABP tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7475

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y6F9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006522

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006513