RAMP1 (NM_005855) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs) . RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Synonyms:

  Receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor-activity modifying protein 1

• Gene ID:

  10267

• UniProt:

  O60894

• Accession Number mRNA:

  NM_005855

• Chromosomal Location:

  2q37.3

• Expression System:

  E. coli

• Tag:

  N-His-Trx

• Related Pathways:

  Vascular smooth muscle contraction

• Field of Research:

  Vascular smooth muscle contraction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  30.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RAMP1

• Species:

  Human

• Protein ID:

  NP_005846

• Overview:

  Purified recombinant protein of Human receptor (G protein-coupled) activity modifying protein 1 (RAMP1), Cys27-Ser117, with N-terminal His-Trx tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10267

• Uniprot URL:

  https://www.uniprot.org/uniprot/O60894

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005855

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005846