TIE2 (TEK) (NM_000459) Human Recombinant Protein

• Background:

  This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF) -like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

• Synonyms:

  CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1

• Gene ID:

  7010

• UniProt:

  Q02763, Q59HG2

• Accession Number mRNA:

  NM_000459

• Chromosomal Location:

  9p21.2

• Expression System:

  E. coli

• Tag:

  N-terminal His-ABP tag

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

• Molecular Weight:

  29.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TEK

• Species:

  Human

• Protein ID:

  NP_000450

• Overview:

  Purified recombinant protein of Human TEK tyrosine kinase, endothelial (TEK), Glu53-Leu174, with N-terminal His-ABP tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7010

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q02763

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000459

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000450