MCP2 (CCL8) (NM_005623) Human Recombinant Protein

• Background:

  This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

• Synonyms:

  HC14; MCP-2; MCP2; SCYA8; SCYA10

• Gene ID:

  6355

• UniProt:

  P80075

• Accession Number mRNA:

  NM_005623

• Chromosomal Location:

  17q12

• Expression System:

  HEK293

• Tag:

  C-DDK

• Related Pathways:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

• Field of Research:

  Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 90% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  9.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCL8

• Species:

  Human

• Protein ID:

  NP_005614

• Overview:

  Purified recombinant protein of Human chemokine (C-C motif) ligand 8 (CCL8), esidues 24-99aa, with C-terminal DDK tag, expressed in human cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6355

• Uniprot URL:

  https://www.uniprot.org/uniprot/P80075

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005623

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005614