NMDAR1 (GRIN1) (NM_007327) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

• Synonyms:

  GluN1; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; NMDAR1; NR1

• Gene ID:

  2902

• UniProt:

  Q05586

• Accession Number mRNA:

  NM_007327

• Chromosomal Location:

  9q34.3

• Expression System:

  CHO

• Tag:

  C-DDK

• Related Pathways:

  Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction

• Field of Research:

  Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane

• Molecular Weight:

  61.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GRIN1

• Species:

  Human

• Protein ID:

  NP_015566

• Overview:

  Purified recombinant protein of Human glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-3, with C-terminal DDK tag, secretory expressed in CHO cells, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2902

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q05586

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007327

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_015566