SRRT Rabbit pAb (APR30352N)

CAT: 0882-APR30352N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR30352N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Acts as a mediator between the cap-binding complex (CBC and the primary microRNAs (miRNAs processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi by miRNAs. Binds capped RNAs (m7GpppG-capped RNA; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SRRT Rabbit pAb (APR30352N) .

Synonyms

SRRT; ARS2; ASR2; serrate

Gene ID

51593

UniProt

Q9BXP5

Cellular Locus

Cytoplasm, Nucleus, nucleoplasm

Applications

IHC (Homo sapiens)

Dilution

IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 96kDa/100kDa Observed MW: Refer to figures

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51593

Uniprot URL

https://www.uniprot.org/uniprot/Q9BXP5

AA Sequence

DYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQSLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF

UniProtKB · Q9BXP5

Serrate RNA effector molecule homolog

SRRT_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9BXP5
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SRRT
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A4D2E5, A4D2E6, A6NK22, B4DJL4, B4DZA6, O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4, Q9Y4S4

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

Activator

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

RNA-mediated gene silencingTranscriptionTranscription regulation

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