[KO Validated] MYOF Rabbit pAb (APR29470N)

• Background:

  Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.

• Synonyms:

  MYOF; FER1L3; myoferlin

• Gene ID:

  26509

• UniProt:

  Q9NZM1

• Cellular Locus:

  Cell membrane, Cytoplasmic vesicle membrane, Nucleus membrane, Single-pass type II membrane protein

• Dilution:

  WB 1:200 - 1:2000

• Form:

  Liquid

• Buffer:

  Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Molecular Weight:

  Calculated MW: 17kDa/46kDa/49kDa/179kDa/229kDa/233kDa/234kDa Observed MW: 260KDa

• Storage Conditions:

  Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] MYOF Rabbit pAb (APR29470N) .

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26509

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NZM1

• AA Sequence:

  Email for sequence