GAPDH Rabbit pAb (APR28871N)

CAT: 0882-APR28871N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR28871N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD) . The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GAPDH Rabbit pAb (APR28871N) .

Synonyms

G3PD; GAPD; HEL-S-162eP; GAPDH

Gene ID

2597

UniProt

P04406

Cellular Locus

Cytoplasm, Membrane, Nucleus, cytoskeleton, cytosol, perinuclear region

Applications

IF (Homo sapiens) IP (Homo sapiens) WB (Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus)

Dilution

WB 1:1000 - 1:10000 IHC 1:50 - 1:100 IF 1:50 - 1:100 IP 1:50 - 1:100

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 31kDa/36kDa Observed MW: 36KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2597

Uniprot URL

https://www.uniprot.org/uniprot/P04406

AA Sequence

MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

UniProtKB · P04406

Glyceraldehyde-3-phosphate dehydrogenase

G3P_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04406
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GAPDH
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: GAPDH
EC number: 1.2.1.12
Processing: —
Secondary accessions: E7EUT4, P00354, Q53X65

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationGlycoproteinIsopeptide bondMethylationOxidationPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisGlycolysisImmunityInnate immunityTranslation regulation

Cellular component

CytoplasmCytoskeletonMembraneNucleus

Ligand

NAD

Molecular function

OxidoreductaseTransferase

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Alternative Products

Catalog	Name
HY-P2804-01	GAPDH, rabbit muscle
MBS9143943-01	GAPDH Rabbit pAb
MBS537510-01	GAPDH protein (Rabbit)
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