DSPP Rabbit pAb (APR28200N)

CAT: 0882-APR28200N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR28200N-01Size:50 µL

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Background

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DSPP Rabbit pAb (APR28200N) .

Synonyms

DSPP; DFNA39; DGI1; DMP3; DPP; DSP

Gene ID

1834

UniProt

Q9NZW4

Cellular Locus

Secreted, extracellular matrix, extracellular space

Applications

WB (Homo sapiens)

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 131kDa Observed MW: 110kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1834

Uniprot URL

https://www.uniprot.org/uniprot/Q9NZW4

AA Sequence

IPVPQSKPLERHVEKSMNLHLLARSNVSVQDELNASGTIKESGVLVHEGDRGRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAETYGHDGIHGKEENITANGIQGQVSIIDNA

UniProtKB · Q9NZW4

Dentin sialophosphoprotein

DSPP_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NZW4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DSPP
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: A8MUI0, O95815

Protein keywords

Biological process

Biomineralization

Ligand

CalciumSialic acid

Disease

DeafnessDisease variant

Cellular component

Extracellular matrixSecreted

PTM

GlycoproteinPhosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

Signal

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