PSEN2 Rabbit pAb (APR27635N)

CAT: 0882-APR27635N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR27635N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PSEN2 Rabbit pAb (APR27635N) .

Synonyms

PSEN2; AD3L; AD4; CMD1V; PS2; STM2

Gene ID

5664

UniProt

P49810

Cellular Locus

Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 46kDa/50kDa Observed MW: 21KDa/35KDa/50KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5664

Uniprot URL

https://www.uniprot.org/uniprot/P49810

AA Sequence

Email for sequence

UniProtKB · P49810

Presenilin-2

PSN2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P49810
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PSEN2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PS-2
EC number: 3.4.23.-
Processing: —
Secondary accessions: A8K8D4, B1AP21, Q96P32

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisCardiomyopathyDisease variantNeurodegeneration

Cellular component

Endoplasmic reticulumEndosomeGolgi apparatusLysosomeMembrane

Molecular function

HydrolaseProtease

Biological process

Notch signaling pathway

PTM

Phosphoprotein

Domain

TransmembraneTransmembrane helix

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