JAK2 Rabbit pAb (APR27614N)

CAT: 0882-APR27614N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR27614N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality JAK2 Rabbit pAb (APR27614N) .

Synonyms

JAK2; JTK10; THCYT3

Gene ID

3717

UniProt

O60674

Cellular Locus

Cytoplasm, Endomembrane system, Nucleus, Peripheral membrane protein

Applications

WB (Homo sapiens, Mus musculus)

Dilution

WB 1:500 - 1:1000 IHC 1:50 - 1:100

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 130kDa Observed MW: 115kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3717

Uniprot URL

https://www.uniprot.org/uniprot/O60674

AA Sequence

Email for sequence

UniProtKB · O60674

Tyrosine-protein kinase JAK2

JAK2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O60674
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: JAK2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.10.2
Processing: —
Secondary accessions: O14636, O75297

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInnate immunity

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Molecular function

Chromatin regulatorKinaseTransferaseTyrosine-protein kinase

Coding sequence diversity

Chromosomal rearrangement

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variantProto-oncogene

PTM

PhosphoproteinUbl conjugation

Domain

RepeatSH2 domain

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