CDKN2B Rabbit pAb (APR26013N)

CAT: 0882-APR26013N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR26013N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDKN2B Rabbit pAb (APR26013N) .

Synonyms

CDKN2B; CDK4I; INK4B; MTS2; P15; TP15; p15INK4b

Gene ID

1030

UniProt

P42772

Cellular Locus

Cytoplasm

Applications

WB (Homo sapiens)

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 8kDa/14kDa Observed MW: 15kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1030

Uniprot URL

https://www.uniprot.org/uniprot/P42772

AA Sequence

MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD

UniProtKB · P42772

Cyclin-dependent kinase 4 inhibitor B

CDN2B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P42772
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CDKN2B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: O15125, Q6FI09

Protein keywords

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Biological process

Cell cycle

Cellular component

Cytoplasm

Technical term

Proteomics identificationReference proteome

Disease

Tumor suppressor

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