NPC2 Rabbit pAb (APR25811N)

CAT: 0882-APR25811N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR25811N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NPC2 Rabbit pAb (APR25811N) .

Synonyms

NPC2; EDDM1; HE1

Gene ID

10577

UniProt

P61916

Cellular Locus

Endoplasmic reticulum, Lysosome, Secreted

Applications

WB (Homo sapiens) IHC (Homo sapiens)

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 13kDa/16kDa Observed MW: 19kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10577

Uniprot URL

https://www.uniprot.org/uniprot/P61916

AA Sequence

EPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL

UniProtKB · P61916

NPC intracellular cholesterol transporter 2

NPC2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P61916
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NPC2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: B4DQV7, Q15668, Q29413

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoprotein

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol metabolismLipid metabolismLipid transportSteroid metabolismSterol metabolismTransport

Disease

Disease variantNiemann-Pick disease

Cellular component

Endoplasmic reticulumLysosomeSecreted

Domain

Signal

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