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Propranolol

CAT: 0804-HY-B0573B-02Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0573B-02Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
CAS Number
525-66-6
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Adrenergic Receptor; Bacterial
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/propranolol.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(COC1=C2C=CC=CC2=CC=C1)CNC(C)C
Molecular Formula
C16H21NO2
Molecular Weight
259.34
Precautions
H315, H319, H320
References & Citations
[1]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70 (5) :1575-84. Epub 2006 Aug 1|[2]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69 (4) :669-73.|[3]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.|[4]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5 (1) :45-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
β adrenergic receptor
Citation 01
Acta Pharm Sin B. 2024 Apr 23.|Adv Sci (Weinh) . 2025 Oct 6:e04817.|Aging Cell. 2025 Jul 26:e70184.|Am J Pathol. 2023 Jul;193 (7) :913-926.|Bone Res. 2024 Mar 21;12 (1) :18.|Chem Eng J. 2025 Oct 17;524:169736.|Environ Toxicol. 2024 Mar;39 (3) :1682-1699.|Exp Neurol. 2023 Jul:365:114418.|Food Chem Toxicol. 2024 Sep 6:114983.|iScience. 2023 Jul 22;26 (9) :107455.|J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 1:1227:123804.|J Immunother Cancer. 2024 Dec 9;12 (12) :e009910.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.|Nat Commun. 2023 May 2;14 (1) :2523.|Pharmaceuticals (Basel) . 2025 Sep 21;18 (9) :1420.|Pharmacol Res Perspect. 2020 Apr;8 (2) :e00575.|Pharmacol Res Perspect. 2021 Oct;9 (5) :e00879.|Phytomedicine. 2024 Aug 19:134:155970.|Phytomedicine. 2025 Jun 18:145:157011.|Redox Biol. 2024 Dec 21:79:103481.|Redox Rep. 2025 Dec;30 (1) :2494314.|Research Square Print. December 21st, 2022.|Sci Signal. 2020 Nov 24;13 (659) :eaax0273.|Transl Psychiatry. 2025 May 17;15 (1) :172.|World J Surg Oncol. 2025 Mar 28;23 (1) :103.|Behav Brain Res. 2022 Feb 10:418:113642.|Biochem Biophys Res Commun. 2023 May 21:657:69-79.|bioRxiv. 2024 November 03.|BMC Pulm Med. 2021 Jun 5;21 (1) :189.|Cell Metab. 2024 Mar 5;36 (3) :466-483.e7.|Cell. 2025 Jan 9;188 (1) :157-174.e22.|Chemosphere. 2019 Jun:225:378-387.|Curr Issues Mol Biol. 2025 Sep 26;47 (10) :798.|Elife. 2024 May 29.|J Endocrinol. 2020 Mar;244 (3) :459-471.|Nature. 2025 Dec;648 (8092) :146-156.|Pharmaceuticals (Basel) . 2025 Sep 21;18 (9) :1420.|Psychopharmacology (Berl) . 2023 Aug;240 (8) :1629-1650.

Chemical Information

Propranolol

Propranolol is a propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3. It has a role as an anxiolytic drug, a beta-adrenergic antagonist, a vasodilator agent, an antihypertensive agent, a xenobiotic, an anti-arrhythmia drug, an environmental contaminant and a human blood serum metabolite. It is a member of naphthalenes, a secondary amine and a propanolamine. It is functionally related to a 1-naphthol.

CAS Number525-66-6
PubChem CID4946
IUPAC Name1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Molecular FormulaC16H21NO2
Molecular Weight259.34
XLogP3
Topological Polar Surface Area41.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count19
Formal Charge0
Complexity257
SMILES
CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
InChI
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
InChIKey
AQHHHDLHHXJYJD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Propranolol
CAS: 525-66-6
CID: 4946
Formula: C16H21NO2
MW: 259.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight259.34
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass259.157228913
Monoisotopic Mass259.157228913
Topological Polar Surface Area41.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity257
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C03592-100mgPropranolol
B6474-100Propranolol glycol
T0812-01Propranolol hydrochloride
C09888-1gPropranolol HCl
CS-O-03093Propranolol-d7
CS-EK-01995Propranolol 13C6
GWB-660682Propranolol Antibody
AR-P03149-01(S) - (-) -Propranolol

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