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TRIM63 Rabbit pAb (APR25124N)

CAT: 0882-APR25124N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR25124N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRIM63 Rabbit pAb (APR25124N) .
Synonyms
TRIM63; IRF; MURF1; MURF2; RNF28; SMRZ
Gene ID
84676
UniProt
Q969Q1
Cellular Locus
Cytoplasm, M line, Nucleus, Z line, myofibril, sarcomere
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 36kDa/40kDa Observed MW: 45KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84676
Uniprot URL
https://www.uniprot.org/uniprot/Q969Q1
AA Sequence
Email for sequence

UniProtKB · Q969Q1

E3 ubiquitin-protein ligase TRIM63

TRI63_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q969Q1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TRIM63
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
B4DN95, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variant

Domain

Coiled coilZinc-finger

Cellular component

CytoplasmNucleus

Ligand

Metal-bindingZinc

Molecular function

Muscle proteinTransferase

Biological process

Ubl conjugation pathway

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