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[KO Validated] GRK2 Rabbit pAb (APR23223N)

CAT: 0882-APR23223N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR23223N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] GRK2 Rabbit pAb (APR23223N) .
Synonyms
GRK2; ADRBK1; BARK1; BETA-ARK1
Gene ID
156
UniProt
P25098
Cellular Locus
Cell membrane, Cytoplasm
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 79kDa Observed MW: 80kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=156
Uniprot URL
https://www.uniprot.org/uniprot/P25098
AA Sequence
LGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL

UniProtKB · P25098

G protein-coupled receptor kinase 2

GRK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25098
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GRK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.16
Processing
—
Secondary accessions
B0ZBE1, Q13837, Q6GTT3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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