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HAP1 Rabbit pAb (APR22916N)

CAT: 0882-APR22916N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR22916N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HAP1 Rabbit pAb (APR22916N) .
Synonyms
HAP1; HAP2; HIP5; HLP; hHLP1
Gene ID
9001
UniProt
P54257
Dilution
WB 1:500 - 1:2000
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 66kDa/67kDa/69kDa/75kDa Observed MW: 76kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9001
Uniprot URL
https://www.uniprot.org/uniprot/P54257
AA Sequence
MRPKRLGRCCAGSRLGPGDPAALTCAPSPSASPAPEPSAQPQARGTGQRVGSRATSGSQFLSEARTGARPASEAGAKAGARRPSAFSAIQGDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIWKTPAAYVGRRPGVSGPERAAFIRELEEALCPNLPPPVKKITQEDVKVMLYLLEELLPPVWESVTYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLEALLGSAKEEIL

UniProtKB · P54257

Huntingtin-associated protein 1

HAP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54257
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HAP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HAP-1
EC number
—
Processing
—
Secondary accessions
A8MQB5, O75358, Q59GK4, Q9H4G3, Q9HA98, Q9NY90
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

AutophagyCilium biogenesis/degradationExocytosisProtein transportTransport

Cellular component

Cell projectionCytoplasmCytoplasmic vesicleCytoskeletonEndoplasmic reticulumEndosomeLysosomeMitochondrionNucleusSynapse

Domain

Coiled coil

Technical term

Proteomics identificationReference proteome

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