SIM2 Rabbit pAb (APR21647N)

CAT: 0882-APR21647N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR21647N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIM2 Rabbit pAb (APR21647N) .

Synonyms

SIM2; HMC13F06; HMC29C01; SIM; bHLHe15

Gene ID

6493

UniProt

Q14190

Cellular Locus

Nucleus

Dilution

WB 1:500 - 1:2000 IHC 1:100 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 63kDa/73kDa Observed MW: 56kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6493

Uniprot URL

https://www.uniprot.org/uniprot/Q14190

AA Sequence

LSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYE

UniProtKB · Q14190

Single-minded homolog 2

SIM2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q14190
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SIM2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: O60766, Q15470, Q15471, Q15472, Q15473, Q16532, Q2TBD8

Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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