TPH2 Rabbit pAb (APR21077N)

CAT: 0882-APR21077N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR21077N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TPH2 Rabbit pAb (APR21076N0) .

Synonyms

TPH2; ADHD7; NTPH

Gene ID

121278

UniProt

Q8IWU9

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 56kDa Observed MW: 54-56kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=121278

Uniprot URL

https://www.uniprot.org/uniprot/Q8IWU9

AA Sequence

MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSR

UniProtKB · Q8IWU9

Tryptophan 5-hydroxylase 2

TPH2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8IWU9
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TPH2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 1.14.16.4
Processing: —
Secondary accessions: A6NGA4, Q14CB0

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingRNA editing

Disease

Disease variant

Ligand

IronMetal-binding

Molecular function

MonooxygenaseOxidoreductase

PTM

Phosphoprotein

Biological process

Serotonin biosynthesis

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