P4HTM Rabbit pAb (APR20174N)

CAT: 0882-APR20174N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR20174N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality P4HTM Rabbit pAb (APR20174N) .

Synonyms

P4HTM; EGLN4; HIFPH4; P4H-TM; PH-4; PH4; PHD4

Gene ID

54681

UniProt

Q9NXG6

Cellular Locus

Endoplasmic reticulum membrane, Single-pass type II membrane protein

Dilution

IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 47kDa/56kDa/63kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54681

Uniprot URL

https://www.uniprot.org/uniprot/Q9NXG6

AA Sequence

RQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNWGLPSILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL

UniProtKB · Q9NXG6

Transmembrane prolyl 4-hydroxylase

P4HTM_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NXG6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: P4HTM
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: P4H-TM
EC number: 1.14.11.29
Processing: —
Secondary accessions: Q6PAG6, Q8TCJ9, Q8WV55, Q96F22, Q9BW77

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumIronMetal-bindingVitamin C

Molecular function

DioxygenaseOxidoreductase

Disease

Disease variantEpilepsyIntellectual disability

Cellular component

Endoplasmic reticulumMembrane

PTM

Glycoprotein

Domain

RepeatSignal-anchorTransmembraneTransmembrane helix

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