CREB3 Rabbit pAb (APR20161N)

CAT: 0882-APR20161N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR20161N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CREB3 Rabbit pAb (APR20161N) .

Synonyms

CREB3; LUMAN; LZIP; sLZIP

Gene ID

10488

UniProt

O43889

Cellular Locus

Cytoplasm, Endoplasmic reticulum membrane, Membrane, Nucleus, Single-pass type II membrane protein

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 39kDa/41kDa/43kDa Observed MW: 44kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10488

Uniprot URL

https://www.uniprot.org/uniprot/O43889

AA Sequence

MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTC

UniProtKB · O43889

Cyclic AMP-responsive element-binding protein 3

CREB3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O43889
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CREB3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CREB-3, cAMP-responsive element-binding protein 3
EC number: —
Processing: —
Secondary accessions: D0PTW6, O14671, O14919, Q5TCV1, Q96GK8, Q9H2W3, Q9UE77

Protein keywords

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Biological process

ChemotaxisHost-virus interactionTranscriptionTranscription regulationUnfolded protein response

Cellular component

CytoplasmEndoplasmic reticulumGolgi apparatusMembraneNucleus

PTM

Glycoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignal-anchorTransmembraneTransmembrane helix

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