NOTCH3 Rabbit pAb (APR20110N)

CAT: 0882-APR20110N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR20110N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NOTCH3 Rabbit pAb (APR20110N) .

Synonyms

NOTCH3; CADASIL; CADASIL1; CASIL; IMF2; LMNS; notch 3

Gene ID

4854

UniProt

Q9UM47

Cellular Locus

Cell membrane, Nucleus, Single-pass type I membrane protein

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 243kDa Observed MW: 280kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4854

Uniprot URL

https://www.uniprot.org/uniprot/Q9UM47

AA Sequence

TPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA

UniProtKB · Q9UM47

Neurogenic locus notch homolog protein 3

NOTC3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9UM47
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NOTCH3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Notch 3
EC number: —
Processing: Precursor
Secondary accessions: Q9UEB3, Q9UPL3, Q9Y6L8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinReceptor

Domain

ANK repeatEGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Cell membraneMembraneNucleus

Biological process

DifferentiationNotch signaling pathwayTranscriptionTranscription regulation

Disease

Disease variant

PTM

Disulfide bondGlycoproteinMethylationPhosphoprotein

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Alternative Products

Catalog	Name
MBS8545169-01	NOTCH3 Rabbit pAb
F0391-100ul	Notch3 Rabbit mAb