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CD46 Rabbit pAb (APR20104N)

CAT: 0882-APR20104N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR20104N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CD46 Rabbit pAb (APR20104N) .
Synonyms
AHUS2; MCP; MIC10; TLX; TRA2.10; CD46
Gene ID
4179
UniProt
P15529
Cellular Locus
Cytoplasmic vesicle, Single-pass type I membrane protein, acrosome inner membrane, secretory vesicle
Dilution
WB 1:500 - 1:2000 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 36kDa/39kDa/40kDa/41kDa/42kDa/43kDa/44kDa Observed MW: 44kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4179
Uniprot URL
https://www.uniprot.org/uniprot/P15529
AA Sequence
TFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPE

UniProtKB · P15529

Membrane cofactor protein

MCP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15529
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD46
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0T1T0, A0T1T1, A0T1T2, Q15429, Q53GV9, Q5HY94, Q5VWS6, Q5VWS7, Q5VWS8, Q5VWS9, Q5VWT0, Q5VWT1, Q5VWT2, Q6N0A1, Q7Z3R5, Q9NNW2, Q9NNW3, Q9NNW4, Q9UCJ4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Complement pathwayFertilizationHost-virus interactionImmunityInnate immunity

Cellular component

Cytoplasmic vesicleMembrane

Disease

Disease variantHemolytic uremic syndrome

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Host cell receptor for virus entryReceptor

Domain

RepeatSignalSushiTransmembraneTransmembrane helix

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