DUSP12 Rabbit pAb (APR19845N)

CAT: 0882-APR19845N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR19845N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DUSP12 Rabbit pAb (APR19845N) .

Synonyms

DUSP12; DUSP1; YVH1

Gene ID

11266

UniProt

Q9UNI6

Cellular Locus

Nucleus

Applications

WB (Mus musculus)

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 37kDa Observed MW: 36kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11266

Uniprot URL

https://www.uniprot.org/uniprot/Q9UNI6

AA Sequence

LMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMGYEVDTSSAIYKQYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVLYKCRKCRRSLFRSSSILDHREGSGPIAFAHKRMTPSSMLTTGRQAQCTSYFI

UniProtKB · Q9UNI6

Dual specificity protein phosphatase 12

DUS12_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9UNI6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DUSP12
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.1.3.16, 3.1.3.48
Processing: —
Secondary accessions: Q5VXA8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmNucleus

Molecular function

HydrolaseProtein phosphatase

Ligand

Metal-bindingZinc

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A2725	DUSP12 Rabbit pAb
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