DYNC2H1 Rabbit pAb (APR19723N)

CAT: 0882-APR19723N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR19723N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DYNC2H1 Rabbit pAb (APR19723N) .

Synonyms

DYNC2H1; ATD3; DHC1b; DHC2; DNCH2; DYH1B; SRPS2B; SRTD3; hdhc11

Gene ID

79659

UniProt

Q8NCM8

Cellular Locus

Cell membrane, Cytoplasm, Peripheral membrane protein, cilium axoneme, cytoskeleton

Dilution

WB 1:500 - 1:2000

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 105kDa/492kDa/493kDa Observed MW: 492kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79659

Uniprot URL

https://www.uniprot.org/uniprot/Q8NCM8

AA Sequence

MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLH

UniProtKB · Q8NCM8

Cytoplasmic dynein 2 heavy chain 1

DYHC2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8NCM8
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DYNC2H1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: O00432, Q16693, Q3C1U8, Q4AC93, Q6ZMX7, Q6ZUM6, Q7Z363, Q8N977, Q92815, Q9HAE4

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCiliumCytoplasmCytoskeletonDyneinMembraneMicrotubule

Disease

CiliopathyDisease variant

Biological process

Cilium biogenesis/degradation

Domain

Coiled coil

Molecular function

Developmental proteinMotor protein

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