ITPR3 Rabbit pAb (APR19405N)

CAT: 0882-APR19405N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR19405N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ITPR3 Rabbit pAb (APR19405N) .

Synonyms

ITPR3; IP3R; IP3R3

Gene ID

3710

UniProt

Q14573

Cellular Locus

Endoplasmic reticulum membrane, Multi-pass membrane protein

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 304kDa Observed MW: 300kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3710

Uniprot URL

https://www.uniprot.org/uniprot/Q14573

AA Sequence

EGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSSEMGTSVLIM

UniProtKB · Q14573

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

ITPR3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q14573
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ITPR3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q14649, Q5TAQ2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

Calcium

Molecular function

Calcium channelIon channelLigand-gated ion channelReceptor

Biological process

Calcium transportIon transportTransport

Disease

Charcot-Marie-Tooth diseaseDisease variantEctodermal dysplasiaNeurodegenerationNeuropathy

Cellular component

Cytoplasmic vesicleEndoplasmic reticulumMembrane

PTM

Disulfide bondPhosphoprotein

Domain

RepeatTransmembraneTransmembrane helix

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