CDK9 Rabbit pAb (APR17576N)

CAT: 0882-APR17576N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR17576N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDK9 Rabbit pAb (APR17576N) .

Synonyms

CDK9; C-2k; CDC2L4; CTK1; PITALRE; TAK

Gene ID

1025

UniProt

P50750

Cellular Locus

Cytoplasm, Nucleus, PML body

Applications

WB (Human colon cancer cell, Homo sapiens)

Dilution

WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 42kDa/53kDa Observed MW: 40KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1025

Uniprot URL

https://www.uniprot.org/uniprot/P50750

AA Sequence

ANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF

UniProtKB · P50750

Cyclin-dependent kinase 9

CDK9_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P50750
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CDK9
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.22, 2.7.11.23
Processing: —
Secondary accessions: Q5JU24, Q5JU25, Q5U006, Q96TF1

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Biological process

DNA damageDNA repairHost-virus interactionTranscriptionTranscription regulation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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